====== Awarded Projects ====== Below is a list of ARM awarded projects. ===== 1998-1999 ===== ^ PI ^ Institution ^ Project Description ^ Amount ^ Funding Type ^ | Dr. Richard Gatti | UCLA | Patient identification and sample collection. | $10,000 | Gift | ===== 1999-2000 ===== ^ PI ^ Institution ^ Project Description ^ Amount ^ Funding Type ^ | Dr. Zohar Argov | Hadassah, Jerusalem | Genotyping and sequencing efforts. | $59,000 | Gift | | Dr. Richard Gatti | UCLA | Patient identification and linkage analysis. | $2,000 | Gift | ===== 2000-2001 ===== ^ PI ^ Institution ^ Project Description ^ Amount ^ Funding Type ^ | Dr. Zohar Argov | Hadassah, Jerusalem | Genotyping and sequencing efforts. | $52,000 | Gift | | Dr. Arastoo Vojdani | Molecular Genetic Lab | Sample collection and genotyping. | $50,000 | Gift | | Dr. Richard Gatti | UCLA | HIBM, Linkage Analysis. | $44,500 | Gift | | Dr. Chaim Jacob | USC | Sample collection and genotyping. | $19,826 | Gift | ===== 2001-2002 ===== ^ PI ^ Institution ^ Project Description ^ Amount ^ Funding Type ^ | Dr. Richard Gatti | UCLA | Linkage analysis, HIBM. | $17,760 | Gift | | Dr. Daniel Darvish | HIBM Research Group | Laboratory startup and sequencing. | $30,000 | Contract | ===== 2002-2003 ===== ^ PI ^ Institution ^ Project Description ^ Amount ^ Funding Type ^ | Dr. Stella Mitrani-Rosenbaum | Hadassah, Jerusalem | Mechanism of pathogenesis of GNE/MNK in HIBM. | $120,000 | Grant 006 | | Dr. Hudson Freeze | UCSD | Initial Analysis and Potential Therapy for HIBM. | $55,806 | Grant 002 | | Dr. Valerie Askanas | USC | h-IBM Research. | $55,000 | Gift | | Dr. Jianping Zheng | USC | Initial Study of antisense GNE/MNK and Over Expression of Mutant GNE in Human Skeletal Muscle Primary Culture System. | $40,535 | Grant 003 | ===== 2003-2004 ===== ^ PI ^ Institution ^ Project Description ^ Amount ^ Funding Type ^ | Dr. Jacques Tremblay | Laval University, Canada | [[grant_008|Transplantation of genetically modified myoblasts from patients with IBM2]]. | $73,000 | Grant 008 | | Dr. Daniel Darvish | HIBM Research Group | Establishment of Cell Culture & Distribution Center for HIBM Research Samples and Reagents. | $56,331 | Grant 010 | | Dr.Kevin Yarema | Johns Hopkins University | Probing the Role of GNE/MNK Mutations in HIBM. | $77,159 | Grant 005 | ===== 2004-2005 ===== ^ PI ^ Institution ^ Project Description ^ Amount ^ Funding Type ^ | Dr. Jacques Tremblay | Laval University, Canada | [[grant_015|Preparation of a clinical trial of transplantation of genetically modified myoblasts to HIBM patients]]. | $92,100 | Grant 015 | | Dr. Kevin Yarema | Johns Hopkins University | [[grant_011|Probing the Role of GNE/MNK Mutations in HIBM (renewal)]]. | $111,872 | Grant 011 | | Dr. Yadira Valles-Ayoub | HIBM Research Group | HIBM testing, and providing reagents and samples, and development of HIBM mouse model. | $261,240 | Contract | ===== 2005-2006 ===== ^ PI ^ Institution ^ Project Description ^ Amount ^ Funding Type ^ | Dr. Jacques Tremblay | Laval University, Canada | [[grant_015|Preparation of a clinical trial of transplantation of genetically modified myoblasts to HIBM patients]]. | $77,159 | Grant 015 | | Dr. Jon Wolff | University of Wisconsin | Preliminary Vector Construction and Validation for HIBM Gene Therapy. | $15,000 | Grant 016 | | Dr. Masashi Kitazawa | UCI | [[grant_013|Impact of Amyloid-beta (Aß) overproduction on a mouse model of Hereditary IBM; Generation of Amyloid Precursor Protein (APP) & GNE double transgenic model]]. | $45,000 | Grant 013 | | Dr. Stella Mitrani-Rosenbaum | Hadassah, Jerusalem | [[grant_017|Establishment of in-vitro and in-vivo experimental systems for Hereditary Inclusion Body Myopathy]]. | $150,000 | Grant 017 | | Dr. Yadira Valles-Ayoub | HIBM Research Group | HIBM testing, maintaining/expanding mouse colony, supporting researchers with samples and reagents | $319,415 | Contract | ===== 2006-2007 ===== ^ PI ^ Institution ^ Project Description ^ Amount ^ Funding Type ^ | Dr. Ajit Varki | UCSD | [[grant_018|Engineering Human-Like Sialic Acids in Mice with HIBM]]. | $81,201 | Grant 018 | | Dr. Jon Wolff | University of Wisconsin | [[grant_019|Gene Therapy for Inclusion Body Myopathy Type II (IBM2)]]. | $100,000 | Grant 019 | | Dr. Yadira Valles-Ayoub | HIBM Research Group | Laboratory Costs, HIBM testing, maintaining/expanding mouse colony, supporting researchers with samples and reagents | $363,894 | Contract | | Dr. John Nemunaitis | Mary Crowley Medical Research Center, TX | Developing Gene Therapy for HIBM | $50,000 | Gift | | Dr. Ichizo Nishino | National Institute of Neurology, Japan | Distal Myopathy with Rimmed Vacuoles (DMRV) & HIBM, Mouse Models | $45,000 | Gift | ===== 2007-2008 ===== ^ PI ^ Institution ^ Project Description ^ Amount ^ Funding Type ^ | Dr. Yadira Valles-Ayoub | HIBM Research Group | Maintaining/expanding mouse colony, improvement of HIBM mouse model, maintaining CLIA and CAP accreditation, and developing Middle-Eastern genetic testing panel | $218,046 | Contract | | Dr. Moises Mallo | Gulbenkian Science Institute | [[grant_024 | Identifying the critical source of sialic acid as a product of GNE activity ]] | $45,000 | Grant 024 | ===== 2008-2010 ===== ^ PI ^ Institution ^ Project Description ^ Amount ^ Funding Type ^ | Dr. Yadira Valles-Ayoub | HIBM Research Group | Maintaining/expanding mouse colony, improvement of HIBM mouse model, developing and validating HIBM (GNE) gene therapy vector, GNE gene therapy toxicology analysis, maintaining CLIA and CAP accreditation, and developing Middle-Eastern genetic testing panel | $107,192 | Contract | | Dr.Perry Shieh | UCLA | Fellowship Award for HIBM (Dr. Shirley Chi) | $65,000 | Fellowship Award | ===== 2010-2011 ===== ^ PI ^ Institution ^ Project Description ^ Amount ^ Funding Type ^ | Dr. Yadira Valles-Ayoub | HIBM Research Group | Phenotype analysis of HIBM mouse model, developing and validating HIBM (GNE) gene therapy vector, in-vitro GNE gene therapy toxicology analysis, obtaining orphan drug designation, maintaining CLIA and CAP accreditation | $214,000 | Grant | ===== 2011-2012 ===== ^ PI ^ Institution ^ Project Description ^ Amount ^ Funding Type ^ | Dr. Yadira Valles-Ayoub | HIBM Research Group | In-vivo GNE gene therapy toxicology analysis, maintaining CLIA and CAP accreditation, developing Middle-Eastern genetic testing panel | $92,414 | Grant | ===== 2012-2013 ===== ^ PI ^ Institution ^ Project Description ^ Amount ^ Funding Type ^ | Dr. Yadira Valles-Ayoub | HIBM Research Group | Continuing pre-clinical toxicology studies, File Investigational New Drug (IND), maintaining mouse colony, maintaining CLIA and CAP accreditation, and launching Middle-Eastern genetic testing panel | $185,160 | Grant | ===== 2013-2014 ===== ^ PI ^ Institution ^ Project Description ^ Amount ^ Funding Type ^ | Dr. Yadira Valles-Ayoub | HIBM Research Group | In-vivo GNE gene therapy toxicology analysis, Maintaining CLIA and CAP accreditation, Maintaining mouse colony, Continuing Middle-Eastern genetic testing Panel. | $193,552 | Grant | ===== 2014-2015 ===== ^ PI ^ Institution ^ Project Description ^ Amount ^ Funding Type ^ | Dr. Yadira Valles-Ayoub | HIBM Research Group | Expanding and continuing Middle-Eastern genetic testing Panel, Maintaining CLIA and CAP accreditation, Maintaining mouse colony. | $37,068 | Grant |